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Cultural differences define diagnosis and genomic medicine practice: implications for undiagnosed diseases

Xiaohong Duan, Thomas Markello, David Adams, Camilo Toro, Cynthia Tifft, William A. Gahl, Cornelius F. Boerkoel

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 389-394 doi: 10.1007/s11684-013-0281-3

Abstract:

Despite the current acceleration and increasing leadership of Chinese genetics research, genetics and its clinical application have largely been imported to China from the Occident. Neither genetics nor the scientific reductionism underpinning its clinical application is integral to the traditional Chinese worldview. Given that disease concepts and their incumbent diagnoses are historically derived and culturally meaningful, we hypothesize that the cultural expectations of genetic diagnoses and medical genetics practice differ between the Occident and China. Specifically, we suggest that an undiagnosed diseases program in China will differ from the recently established Undiagnosed Diseases Program at the United States National Institutes of Health; a culturally sensitive concept will integrate traditional Chinese understanding of disease with the scientific reductionism of Occidental medicine.

Keywords： genetics     cultural differences     undiagnosed diseases program    

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Rare-earth separation based on the differences of ionic magnetic moment via quasi-liquid strategy

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 10,   Pages 1584-1594 doi: 10.1007/s11705-022-2189-4

Abstract: Based on the tiny differences of ionic radius, solvent extraction has been developed as the “mass methodThe differences of the ionic magnetic moment among rare earths are greater than that of ionic radius.Herein, a novel method based on the large ionic magnetic moment differences of rare earth elements wasthen the ordering degree of them was improved with the Z-bond effect, and finally the magnetic moment differences

Keywords： rare earth element     different magnetic moment     magnetic separation     ionic liquid    

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MHD effect on the critical temperature differences of oscillatory thermocapillary convection in two-layer

Hulin HUANG, Xiaoming ZHOU,

Frontiers in Energy 2010, Volume 4, Issue 2,   Pages 155-160 doi: 10.1007/s11708-009-0063-4

Abstract: The effect of different directional magnetic fields on critical temperature differences of oscillatorycan delay the transition from steady convection to oscillatory convection, and critical temperature differences

Keywords： magnetohydrodynamic     magnetic fields     thermocapillary convection     critical temperature difference     oscillatory convection     two-layer fluid system    

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Functional trait differences between native bunchgrasses and the invasive grass

Huiqin HE, Thomas A. MONACO, Thomas A. JONES

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 1,   Pages 139-147 doi: 10.15302/J-FASE-2017175

Abstract: Differences among perennial grasses were more pronounced for physiological traits under infrequent watering

Keywords： annual grass     comparative growth     drought response     invasive plant     native grass     specific leaf area     soil-water use    

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Multiphase redistribution differences of polycyclic aromatic hydrocarbons (PAHs) between two successive

Rufeng LI,Chenghong FENG,Dongxin WANG,Baohua LI,Zhenyao SHEN

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 2,   Pages 381-389 doi: 10.1007/s11783-015-0817-7

Abstract: Successive sediment suspensions often happen in estuary, yet little research has probed into the difference in the release behaviors of organic compounds among different suspensions. This study took polycyclic aromatic hydrocarbons (PAHs) as typical organic contaminants and investigated the release behaviors between two successive suspensions with a particle entrainment simulator (PES). Results showed that successive sediment suspensions lowered the concentration of dissolved PAHs in the overlying water via facilitating the re-adsorption of dissolved PAHs onto the suspended particles. Fast-release and slow-release periods of PAHs were successively observed in the both suspensions. The concentration changes of dissolved PAHs in the second suspension were generally similar with but hysteretic to those in the first suspension. More vigorous desorption and re-absorption of PAHs were induced in the second suspension. Successive sediment suspensions obviously decreased the concentrations of mineral composition and organic matters in the overlying water, which significantly affects multiphase distribution of PAHs.

Keywords： sediment suspension     PAHs     multiphase distribution     distribution coefficients    

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Phosphate-induced differences in stabilization efficiency for soils contaminated with lead, zinc, and

Jie Ren, Zhuo Zhang, Mei Wang, Guanlin Guo, Ping Du, Fasheng Li

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 2, doi: 10.1007/s11783-018-1006-2

Abstract: This approach provides insight into phosphate-induced differences in stabilization efficiency in soils

Keywords： Heavy metals     Metal-contaminated soil     Phosphate     Competitive stabilization    

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Visualization of amino acid composition differences between processed protein from different animal species

Xingfan ZHOU,Zengling YANG,Longjian CHEN,Lujia HAN

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 171-179 doi: 10.15302/J-FASE-2016095

Abstract: dominant organic components of processed animal proteins, however there has been limited investigation of differencesInformation on these differences will not only be helpful for their further utilization but also provideSOFM display the similarities and differences in amino acid composition between protein sources and effectivelycomposition was shown to be useful for distinguishing fish meal from MBM due to their large concentration differences

Keywords： self-organizing feature maps     visualization     processed animal proteins (PAPs)     amino acid    

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Gender differences in the relationship between plasma lipids and fasting plasma glucose in non-diabetic

Jie Zheng,Yuzhen Gao,Yuejuan Jing,Xiaoshuang Zhou,Yuanyuan Shi,Yanhong Li,Lihua Wang,Ruiying Wang,Maolian Li,Chuanshi Xiao,Yafeng Li,Rongshan Li

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 477-483 doi: 10.1007/s11684-014-0346-y

Abstract:

The association between dyslipidemia and elevated fasting glucose in type 2 diabetes is well known. In non-diabetes, whether this association still exists, and whether dyslipidemia is an independent risk factor for high fasting plasma glucose (FPG) levels are not clear. This cross-sectional study recruited 3460 non-diabetic Chinese subjects (1027 men, and 2433 women, aged 35–75 years old) who participated in a health survey. Men and women were classified into tertiles by levels of plasma lipids respectively. In women, the prevalence of impaired fasting glucose (IFG) was decreased with increased HDL-C. A stepwise increase in HDL-C was associated with decreasing FPG levels (lowest tertiles, FPG: 5.376±0.018; middle tertiles, 5.324±0.018; highest tertiles, 5.276±0.018 mmol/L; P=0.001). Reversely, FPG levels increased from lowest tertiles to highest tertiles of LDL-C, TC, and TG. we found that women in the first tertile with lower HDL-C level had a 1.75-fold increase in risk of IFG compared with non-diabetic women in the third tertile with higher HDL-C level (OR: 1.75; 95% CI: 1.20--2.56). In men, no significant association was found. We took age, BMI, waist/hip ratio, education, smoking, alcohol drinking, and physical exercise as adjusted variables. In Chinese non-diabetic women, dyslipidemia is independently associated with high levels of FPG; TG, HDL-C, and LDL-C are predictors of IFG independent of BMI and waist/hip ratio.

Keywords： dyslipidemia     plasma lipids     plasma fasting glucose     impaired fasting glucose     non-diabetes    

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Differences in distributions, assembly mechanisms, and putative interactions of AOB and NOB at a large

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 10, doi: 10.1007/s11783-023-1722-0

Abstract:

● Nitrifiers in WWTP were investigated at large spatial scale.

Keywords： Activated sludge     Spatial distributions     Microbial assembly     Co-occurrence patterns     Nitrifying bacteria    

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Comparison study on accumulation & distribution of tight sandstone gas between China and the United States and its significance

Tong Xiaoguang,Guo Bincheng,Li Jianzhong,Huang Fuxi

Strategic Study of CAE 2012, Volume 14, Issue 6,   Pages 9-15

Abstract:

The tight gas has already been the important field of the global unconventional resource exploration. The distribution of tight gas in China is very wide; for example, the scale development of Ordos Basin and Sichuan Basin have been achieved. The Rokey Mountain in the United States is the area where the tight gas is well developed. Comparative study on the generation condition and reservoir characters of American tight gas is the useful way to accelerate the development of tight gas and open up the thought of exploration. The result of comparative analysis of tight gas reservoir between China and the United States shows: tight gas of China and the United States havs many common characters, for example, most source rock being coal measure strata, tight reservoir, abnormal formation pressure, resource and reservoir intimate contract and gas reservoir gross distribution and so on; otherness is mainly reflected in tight gas source depositional environment,thermal evolution extent, reservoir heterogeneity, densifying factor, the longitudinal and plane distribution characteristics of gas reservoir. The main factors of are the character of depositional basin, sedimentary environment and deuterogene tectonic feature. In allusion to the particularity of Chinese tight gas, the key points of tight gas exploration and development are intensifying reservoir heterogeneity, high grade reservoir forecast, and the study of gas reservoir distribution and striving to make technological breakthrough to increase well cumulative production.

Keywords： tight sandstone gas     accumulation condition     differences    

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Strategic Thinking and Suggestions on Promoting Regional Energy Revolution Based on Local Conditions

Xie Kechang

Strategic Study of CAE 2021, Volume 23, Issue 1,   Pages 1-6 doi: 10.15302/J-SSCAE-2021.01.001

Abstract: Therefore, China should consider these significant differences in regional development while promoting

Keywords： regional energy revolution     regional development differences     coordinated development     new development    

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Differences in microstructure and properties between selective laser melting and traditional manufacturing

Bo SONG,Xiao ZHAO,Shuai LI,Changjun HAN,Qingsong WEI,Shifeng WEN,Jie LIU,Yusheng SHI

Frontiers of Mechanical Engineering 2015, Volume 10, Issue 2,   Pages 111-125 doi: 10.1007/s11465-015-0341-2

Abstract:

Selective laser melting (SLM), as one of the additive manufacturing technologies, is widely investigated to fabricate metal parts. In SLM, parts are manufactured directly from powders in a layer-by-layer fashion; SLM also provides several advantages, such as production of complex parts with high three-dimensional accuracy, compared with other additive manufacturing technologies. Therefore, SLM can be applied in aeronautics, astronautics, medicine, and die and mould industry. However, this technique differs from traditional methods, such as casting and forging; for instance, the former greatly differs in terms of microstructure and properties of products. This paper summarizes relevant studies on metal material fabrication through SLM. Based on a work completed in Huazhong Univ. Sci Tech., Rapid Manuf. Center (HUST-RMC) and compared with characteristics described in other reported studies, microstructure, properties, dimensional accuracy, and application of SLM are presented.

Keywords： selective laser melting     microstructure     performance     application    

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Engineering for Inclusion: Empowering Individuals with Physical and Neurological Differences through

Peter T. Cummings, Philippe M. Fauchet, Michael Goldfarb, Martha W.M. Jones, Maithilee Kunda, Jonathan B. Perlin, Nilanjan Sarkar, Keivan G. Stassun, Zachary E. Warren, Karl E. Zelik

Engineering 2021, Volume 7, Issue 2,   Pages 141-143 doi: 10.1016/j.eng.2020.06.020

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Genetic and Functional Differences of Escherichia coli Strains from Colorectal Cancer Mucosal Article

Yuxiao Chang, Xiang Li, Lei Ding, Chao Yang, Zhiyuan Pan, Ni Han, Yujun Cui, Fachao Zhi, Ruifu Yang, Hong Gao, Yujing Bi

Engineering 2022, Volume 16, Issue 9,   Pages 210-219 doi: 10.1016/j.eng.2021.03.028

Abstract: culturomics to isolate CRC mucosal samples and selected 158 Escherichia coli strains to reveal their differencespathways in the different phylogroups, which can improve the current understanding of the phenotypic differencesThe strain differences revealed in both genomics and functions indicate that the microbiota’s function

Keywords： Colorectal cancer     Gut microbiota     Culturomics     Escherichia coli     Strain level    

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Differences in Immunoglobulin G Glycosylation Between Influenza and COVID-19 Patients Article

Marina Kljaković-Gašpić Batinjan, Tea Petrović, Frano Vučković, Irzal Hadžibegović, Barbara Radovani, Ivana Jurin, Lovorka Đerek, Eva Huljev, Alemka Markotić, Ivica Lukšić, Irena Trbojević-Akmačić, Gordan Lauc, Ivan Gudelj, Rok Čivljak

Engineering 2023, Volume 26, Issue 7,   Pages 54-62 doi: 10.1016/j.eng.2022.08.007

Abstract:

The essential role of immunoglobulin G (IgG) in immune system regulation and combatting infectious diseases cannot be fully recognized without an understanding of the changes in its N-glycans attached to the asparagine 297 of the Fc domain that occur under such circumstances. These glycans impact the antibody stability, half-life, secretion, immunogenicity, and effector functions. Therefore, in this study, we analyzed and compared the total IgG glycome—at the level of individual glycan structures and derived glycosylation traits (sialylation, galactosylation, fucosylation, and bisecting N-acetylglucosamine (GlcNAc))—of 64 patients with influenza, 77 patients with coronavirus disease 2019 (COVID-19), and 56 healthy controls. Our study revealed a significant decrease in IgG galactosylation, sialylation, and bisecting GlcNAc (where the latter shows the most significant decrease) in deceased COVID-19 patients, whereas IgG fucosylation was increased. On the other hand, IgG galactosylation remained stable in influenza patients and COVID-19 survivors. IgG glycosylation in influenza patients was more time-dependent: In the first seven days of the disease, sialylation increased and fucosylation and bisecting GlcNAc decreased; in the next 21 days, sialylation decreased and fucosylation increased (while bisecting GlcNAc remained stable). The similarity of IgG glycosylation changes in COVID-19 survivors and influenza patients may be the consequence of an adequate immune response to enveloped viruses, while the observed changes in deceased COVID-19 patients may indicate its deviation.

Keywords： Influenza     COVID-19     Viral infection     Glycosylation     Immunoglobulin G     Pneumonia    

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Title Author Date Type Operation

Cultural differences define diagnosis and genomic medicine practice: implications for undiagnosed diseases

Xiaohong Duan, Thomas Markello, David Adams, Camilo Toro, Cynthia Tifft, William A. Gahl, Cornelius F. Boerkoel

Journal Article

Rare-earth separation based on the differences of ionic magnetic moment via quasi-liquid strategy

Journal Article

MHD effect on the critical temperature differences of oscillatory thermocapillary convection in two-layer

Hulin HUANG, Xiaoming ZHOU,

Journal Article

Functional trait differences between native bunchgrasses and the invasive grass

Huiqin HE, Thomas A. MONACO, Thomas A. JONES

Journal Article

Multiphase redistribution differences of polycyclic aromatic hydrocarbons (PAHs) between two successive

Rufeng LI,Chenghong FENG,Dongxin WANG,Baohua LI,Zhenyao SHEN

Journal Article

Phosphate-induced differences in stabilization efficiency for soils contaminated with lead, zinc, and

Jie Ren, Zhuo Zhang, Mei Wang, Guanlin Guo, Ping Du, Fasheng Li

Journal Article

Visualization of amino acid composition differences between processed protein from different animal species

Xingfan ZHOU,Zengling YANG,Longjian CHEN,Lujia HAN

Journal Article

Gender differences in the relationship between plasma lipids and fasting plasma glucose in non-diabetic

Jie Zheng,Yuzhen Gao,Yuejuan Jing,Xiaoshuang Zhou,Yuanyuan Shi,Yanhong Li,Lihua Wang,Ruiying Wang,Maolian Li,Chuanshi Xiao,Yafeng Li,Rongshan Li

Journal Article

Differences in distributions, assembly mechanisms, and putative interactions of AOB and NOB at a large

Journal Article

Comparison study on accumulation & distribution of tight sandstone gas between China and the United States and its significance

Tong Xiaoguang,Guo Bincheng,Li Jianzhong,Huang Fuxi

Journal Article

Strategic Thinking and Suggestions on Promoting Regional Energy Revolution Based on Local Conditions

Xie Kechang

Journal Article

Differences in microstructure and properties between selective laser melting and traditional manufacturing

Bo SONG,Xiao ZHAO,Shuai LI,Changjun HAN,Qingsong WEI,Shifeng WEN,Jie LIU,Yusheng SHI

Journal Article

Engineering for Inclusion: Empowering Individuals with Physical and Neurological Differences through

Peter T. Cummings, Philippe M. Fauchet, Michael Goldfarb, Martha W.M. Jones, Maithilee Kunda, Jonathan B. Perlin, Nilanjan Sarkar, Keivan G. Stassun, Zachary E. Warren, Karl E. Zelik

Journal Article

Genetic and Functional Differences of Escherichia coli Strains from Colorectal Cancer Mucosal

Yuxiao Chang, Xiang Li, Lei Ding, Chao Yang, Zhiyuan Pan, Ni Han, Yujun Cui, Fachao Zhi, Ruifu Yang, Hong Gao, Yujing Bi

Journal Article

Differences in Immunoglobulin G Glycosylation Between Influenza and COVID-19 Patients

Marina Kljaković-Gašpić Batinjan, Tea Petrović, Frano Vučković, Irzal Hadžibegović, Barbara Radovani, Ivana Jurin, Lovorka Đerek, Eva Huljev, Alemka Markotić, Ivica Lukšić, Irena Trbojević-Akmačić, Gordan Lauc, Ivan Gudelj, Rok Čivljak

Journal Article